Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G2QH
|
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| Former ID |
DCL000361
|
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| Drug Name |
AEE-788
|
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| Synonyms |
AEE; AEE 788; AEE788; GNF-Pf-5343; AEE-788, NVP-AEE 788, AEE788
|
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| Drug Type |
Small molecular drug
|
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| Therapeutic Class |
Anticancer Agents
|
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| Company |
Novartis AG
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H32N6
|
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| InChI |
InChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1
|
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| InChIKey |
OONFNUWBHFSNBT-HXUWFJFHSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Fibroblast growth factor receptor 2 | Target Info | Inhibitor | [536474] | |
| FGF-3 receptor | Target Info | Inhibitor | [536474] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Ras signaling pathway | |||||
| Rap1 signaling pathway | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Regulation of actin cytoskeleton | |||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| Central carbon metabolism in cancerhsa04010:MAPK signaling pathway | |||||
| MicroRNAs in cancer | |||||
| Bladder cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| PANTHER Pathway | FGF signaling pathwayP00021:FGF signaling pathway | ||||
| Pathway Interaction Database | FGF signaling pathway | ||||
| WikiPathways | Regulation of Actin Cytoskeleton | ||||
| Ectoderm Differentiation | |||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Cardiac Hypertrophic Response | |||||
| Signaling Pathways in Glioblastoma | |||||
| Neural Crest Differentiation | |||||
| Signaling by FGFR | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| AngiogenesisWP51:Regulation of Actin Cytoskeleton | |||||
| Endochondral Ossification | |||||
| Bladder Cancer | |||||
| References | |||||
| Ref 521635 | ClinicalTrials.gov (NCT00107237) AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme. U.S. National Institutes of Health. | ||||
| Ref 542626 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7643). | ||||
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