Drug Information

Drug General Information
Drug ID
D0CI9T
Former ID
DCL000744
Drug Name
Ceftobiprole
Synonyms
BAL 9141; BAL 9141-000; BAL-9141; Ro 63-9141; Ro-63-9141; Ro-63-9141/000; (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-ylidene)-2-nitrosoacetyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)-pyrrolidin-3-yl]pyrrolidin-3-ylidene]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Drug Type
Small molecular drug
Indication Intensive care unit; Bacterial infections [ICD9: 001-009, 001-139, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Phase 1 [536773]
Company
Johnson & Johnson
Structure
Download
2D MOL

3D MOL
Formula
C20H22N8O6S2
Canonical SMILES
C1CNCC1N2CCC(=CC3=C(N4C(C(C4=O)NC(=O)C(=C5NSC(=N5)N)N=O<br />)SC3)C(=O)O)C2=O
InChI
1S/C20H22N8O6S2/c21-20-24-14(26-36-20)11(25-34)15(29)23-12-17(31)28-13(19(32)33)9(7-35-18(12)28)5-8-2-4-27(16(8)30)10-1-3-22-6-10/h5,10,12,18,22,26H,1-4,6-7H2,(H2,21,24)(H,23,29)(H,32,33)/b8-5+,14-11-/t10-,12-,18-/m1/s1
InChIKey
LXLDMYXULSBRCX-HZEONMFJSA-N
CAS Number
CAS 209467-52-7
PubChem Compound ID
6918430
PubChem Substance ID
12015243, 14861090, 14910117, 14910118, 43529800, 50941224, 57371924, 114787956, 123109439, 134339237, 135195559, 152186866, 164045168, 175426903, 176229921, 215781651, 228761175, 235584981
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Modulator [552696]
References
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 552696Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother. 2007 Jul;51(7):2621-4. Epub 2007 Apr 30.

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