Drug Information

Drug General Information
Drug ID
D07EXV
Former ID
DNC003905
Drug Name
XEMILOFIBAN
Drug Type
Small molecular drug
Indication Peripheral vascular disease [ICD9: 443.9; ICD10:I73.9] Discontinued in Phase 3 [545736]
Structure
Download
2D MOL

3D MOL
Formula
C18H22N4O4
Canonical SMILES
CCOC(=O)CC(C#C)NC(=O)CCC(=O)NC1=CC=C(C=C1)C(=N)N
InChI
1S/C18H22N4O4/c1-3-13(11-17(25)26-4-2)21-15(23)9-10-16(24)22-14-7-5-12(6-8-14)18(19)20/h1,5-8,13H,4,9-11H2,2H3,(H3,19,20)(H,21,23)(H,22,24)/t13-/m1/s1
InChIKey
ZHCINJQZDFCSEL-CYBMUJFWSA-N
PubChem Compound ID
60957
Target and Pathway
Target(s) mRNA of integrin beta 3 Target Info Inhibitor [525656]
KEGG Pathway Rap1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Osteoclast differentiation
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
NetPath Pathway Leptin Signaling Pathway
Pathway Interaction Database IL4-mediated signaling events
Integrin family cell surface interactions
Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Osteopontin-mediated events
Nectin adhesion pathway
Arf6 signaling events
S1P1 pathway
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
Ephrin B reverse signaling
Reactome Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways Monoamine Transport
TGF beta Signaling Pathway
Osteoblast Signaling
Focal Adhesion
Hematopoietic Stem Cell Differentiation
Human Complement System
Syndecan interactions
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
Cell surface interactions at the vascular wall
Serotonin Transporter Activity
Osteopontin Signaling
Osteoclast Signaling
References
Ref 545736Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004434)
Ref 525656J Med Chem. 1999 Dec 16;42(25):5254-65.Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.