Drug Information

Drug General Information
Drug ID
D09XUB
Former ID
DCL000278
Drug Name
Viramidine
Synonyms
Ribamidine; Prodrug of Ribavirin; Ribavirin amidine; Taribavirin hydrochloride; ICN 3142; AVS-000206; AVS-206;ICN-3142; Taribavirin hydrochloride (USAN); Viramidine (TN); 1-.Beta.-D-Ribofuranosyl-1,2,4-triazole-3-carboximidine hydrochloride; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboximidamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboximidamide hydrochloride; 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboximidine
Drug Type
Small molecular drug
Indication HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Phase 3 [530252]
Company
Valeant Pharmaceuticals International
Structure
Download
2D MOL

3D MOL
Formula
C8H13N5O4
Canonical SMILES
C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=N)N
InChI
1S/C8H13N5O4/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8/h2-5,8,14-16H,1H2,(H3,9,10)/t3-,4-,5-,8-/m1/s1
InChIKey
NHKZSTHOYNWEEZ-AFCXAGJDSA-N
CAS Number
CAS 119567-79-2
PubChem Compound ID
451448
PubChem Substance ID
596075, 10300687, 14823240, 15220993, 57405261, 76812438, 104644222, 126666025, 128702863, 135241680, 137115114, 184526523, 198969183, 223656176, 226425864, 242550043
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase Target Info Inhibitor [536317]
References
Ref 530252A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment-na?ve patients with chronic hepatitis C: ViSER1 results. Hepatology. 2009 Sep;50(3):717-26.
Ref 536317Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.

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