Drug General Information
Drug ID
D07KYT
Former ID
DNCL002109
Drug Name
AC220
Synonyms
Quizartinib
Drug Type
Small molecular drug
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 3 [524603]
Company
Ambit Biosciences; Astellas Pharma US
Structure
Download
2D MOL

3D MOL

Formula
C29H32N6O4S
Canonical SMILES
CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C<br />=C5)OCCN6CCOCC6)SC4=N3
InChI
1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChIKey
CVWXJKQAOSCOAB-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 524603ClinicalTrials.gov (NCT02039726) An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects. U.S. National Institutes of Health.

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