Drug General Information
Drug ID	D05FUU
Former ID	DIB012715
Drug Name	Pratosartan
Synonyms	KD3-671; KT3-671
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Phase 3	[545261]
Company	Kotobuki Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C25H26N6O
Canonical SMILES	n1(c2c(nc1CCC)CCCCC2=O)Cc1ccc(c2c(c3nnn[nH]3)cccc2)cc1
CAS Number	CAS 153804-05-8
PubChem Compound ID	9802561
Target and Pathway
Target(s)	Type-1 angiotensin II receptor	Target Info	Antagonist	[529390]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Renin-angiotensin system
	Renin secretion
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway	Angiotensin Metabolism
	Muscle/Heart Contraction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Allograft Rejection
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545261	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002623)
Ref 529390	Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.