Drug Information

Drug General Information
Drug ID
D01UXW
Former ID
DNC000958
Drug Name
Morphine-6-glucuronide
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 3 [522966]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C23H27NO9
Canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)OC6C(C(C(C(O6)C<br />(=O)O)O)O)O
InChI
1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1
InChIKey
GNJCUHZOSOYIEC-GAROZEBRSA-N
CAS Number
CAS 20290-10-2
PubChem Compound ID
5360621
PubChem Substance ID
11653771, 14784697, 14858183, 39384018, 47808597, 49972680, 51090907, 57362024, 74617247, 103416752, 127978722, 134223413, 134339010, 134340238, 134994549, 137242529, 160849580, 162222762, 198990027, 223445569, 225014733, 226517416
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [536058]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 522966ClinicalTrials.gov (NCT01082471) An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours. U.S. National Institutes of Health.
Ref 536058Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71.

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