Drug Information
Drug General Information | |||||
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Drug ID |
D01GFX
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Former ID |
DNC010680
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Drug Name |
OSI-906
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C26H23N5O
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InChI |
InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+
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InChIKey |
PKCDDUHJAFVJJB-VLZXCDOPSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
16743657, 23744765, 57275263, 74532058, 103749228, 103905463, 104150248, 131480754, 134347885, 135262588, 135626662, 136340263, 136350036, 136367290, 136367850, 137275876, 137553219, 137553254, 137553468, 144116323, 152258112, 152344419, 160646951, 162011565, 162038063, 162202653, 164041951, 170500763, 174531077, 177748835, 178103995, 180416100, 184816222, 189024767, 196408579, 198945656, 223704703, 226728959, 226729306, 226729307, 235565420, 241383573, 242533722, 242845726, 243364150, 244256025, 247345853, 252160378, 252215970, 252440138
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Target and Pathway | |||||
Target(s) | Insulin-like growth factor I receptor | Target Info | Inhibitor | [530811] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
HIF-1 signaling pathway | |||||
FoxO signaling pathway | |||||
Oocyte meiosis | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
AMPK signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Signaling pathways regulating pluripotency of stem cells | |||||
Long-term depression | |||||
Ovarian steroidogenesis | |||||
Progesterone-mediated oocyte maturation | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Proteoglycans in cancer | |||||
Glioma | |||||
Prostate cancer | |||||
Melanoma | |||||
References | |||||
Ref 522702 | ClinicalTrials.gov (NCT00924989) A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma. U.S. National Institutes of Health. | ||||
Ref 542447 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7423). |
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