Drug Information

Drug General Information
Drug ID
D09QBG
Former ID
DNCL001859
Drug Name
Cangrelor
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [521896], [539125]
Company
The Medicines Company
Structure
Download
2D MOL

3D MOL
Formula
C17H25Cl2F3N5O12P3S2
InChI
InChI=1S/C17H25Cl2F3N5O12P3S2/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32)/t8-,10-,11-,14-/m1/s1
InChIKey
PAEBIVWUMLRPSK-IDTAVKCVSA-N
PubChem Compound ID
9854012
PubChem Substance ID
14840449, 14889113, 17397508, 24148737, 45276318, 57373557, 74406608, 92729766, 103366287, 104011562, 135195441, 135650051, 137249379, 138458592, 162220708, 180371538, 198960207, 223660999, 231868289, 248489331, 249816420, 251966660, 252215097, 252447147
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Antagonist [543771]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 521896ClinicalTrials.gov (NCT00385138) Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition.. U.S. National Institutes of Health.
Ref 539125(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1776).
Ref 543771(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).

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