Drug General Information
Drug ID	D09YDQ
Former ID	DIB007566
Drug Name	STX-107
Drug Type	Small molecular drug
Indication	Autism [ICD9: 299; ICD10:F84.0]		Phase 2	[523414], [540295]
Company	Merck Research Laboratories
Structure		Download 2D MOL 3D MOL
Formula	C11H8N2S
InChIKey	NRBNGHCYDWUVLC-UHFFFAOYSA-N
PubChem Compound ID	9794218
PubChem Substance ID	14748695, 24104567, 26759129, 44830237, 50032808, 53788182, 53800678, 57373328, 79845870, 99431565, 103255826, 104015378, 134342103, 135311599, 137005482, 139599414, 162512600, 163687720, 178100367, 196376186, 208264895, 226547123, 243042021
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Antagonist	[544372]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523414	ClinicalTrials.gov (NCT01325740) A Study to Assess the Tolerability of a Single Dose of STX107 in Adults With Fragile X Syndrome. U.S. National Institutes of Health.
Ref 540295	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3336).
Ref 544372	Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30.

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