Drug Information

Drug General Information
Drug ID
D0E3LP
Former ID
DIB001314
Drug Name
SEN-196
Synonyms
EX-527; SEN-0014196; SIRT1 inhibitors (Huntingtons disease), Elixir/Siena; Sirtuin-1 inhibitors (oral, Huntington's disease), Elixir/Siena
Drug Type
Small molecular drug
Indication Huntington's disease [ICD9: 294.1, 333.4; ICD10:F02.2, G10] Phase 2 [523783], [542972]
Company
Elixir Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C13H13ClN2O
InChI
InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
InChIKey
FUZYTVDVLBBXDL-UHFFFAOYSA-N
PubChem Compound ID
5113032
PubChem Substance ID
7580502, 8564414, 12015946, 16240238, 26759529, 38735740, 47524531, 48268974, 51138214, 57357382, 91106622, 103472591, 104064042, 106911508, 113739208, 117703564, 118266473, 124391161, 124584355, 125333921, 126600655, 126729602, 134224869, 135698424, 136343732, 136348247, 136367542, 136920325, 136946492, 142864246, 143403468, 144115966, 162037658, 162150401, 162202713, 163134614, 163620889, 163640315, 163686210, 163687326, 164045122, 164194033, 170305960, 172131328, 175608116, 181777870, 184597282, 185989927, 202562862, 208265236
Target and Pathway
Target(s) NAD-dependent deacetylase sirtuin-1 Target Info Inhibitor [531699]
KEGG Pathway FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of Androgen receptor activity
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian Clock
WikiPathways Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathway
References
Ref 523783ClinicalTrials.gov (NCT01521585) A Phase II Safety and Tolerability Study With SEN0014196. U.S. National Institutes of Health.
Ref 542972(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8100).
Ref 531699Sirtuin 1 (SIRT1): the misunderstood HDAC. J Biomol Screen. 2011 Dec;16(10):1153-69.

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