Drug Information

Drug General Information
Drug ID
D0K0IS
Former ID
DIB007295
Drug Name
Polyglutamate camptothecin
Synonyms
CT-2106; PG-interferon; Polyglutamate camptothecin, Cell Therapeutics; Polyglutamate-camptothecin; CPT-Gly-PG; Camptothecin-glycine-polyglutamate; PG-CPT, Cell Therapeutics; PG-camptothecin, CT; Polyglutamate-linked anticancer agents, Cell Therapeutics; PG-G-CSF, Cell Therapeutics
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [521802]
Company
Cell Therapeutics Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
*C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N*)CCC(=O)O)CCC(<br />=O)NCC(=O)O[C@@]1(CC)c2c(c(=O)n3c(c4c(C3)cc3c(n4)cccc3)<br />c2)COC1=O)CCC(=O)O
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [528447]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 521802ClinicalTrials.gov (NCT00291837) CT-2106 for the Second Line Treatment of Ovarian Cancer. U.S. National Institutes of Health.
Ref 528447Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.

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