Drug Information

Drug General Information
Drug ID
D05BJD
Former ID
DAP001406
Drug Name
Motexafin gadolinium
Synonyms
Xcytrin; Gadolinium texaphyrin; GdT2B2; GD-Tex; Motexafin gadolinium (USAN); PCI-0120; Xcytrin (TN)
Drug Type
Small molecular drug
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Approved [535596]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 3 [537003]
Therapeutic Class
Anticancer Agents
Company
Pharmacyclics, Inc
Structure
Download
2D MOL

3D MOL
Formula
C52H74GdN5O15
Canonical SMILES
CCC1=C(C2=CC3=NC(=CN=C4C=C(C(=CC4=NC=C5C(=C(C(=N5)C=C1[<br />N-]2)CCCO)C)OCCOCCOCCOC)OCCOCCOCCOC)C(=C3CCCO)C)CC.CC(=<br />O)[O-].CC(=O)[O-].O.[Gd+3]
InChI
1S/C48H66N5O10.2C2H4O2.Gd.H2O/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);;1H2/q-1;;;+3;/p-2
InChIKey
KHDBHVDCUGRVLA-UHFFFAOYSA-L
CAS Number
CAS 156436-89-4
PubChem Compound ID
23724967
PubChem Substance ID
47206807, 56053293, 57388141, 198947535
ChEBI ID
ChEBI:50162
Target and Pathway
Target(s) Thioredoxin reductase Target Info Modulator [537003]
References
Ref 535596Photodynamic therapy: applications in atherosclerotic vascular disease with motexafin lutetium. Catheter Cardiovasc Interv. 2002 Nov;57(3):387-94.
Ref 537003Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9. Epub 2009 Jan 1.
Ref 537003Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9. Epub 2009 Jan 1.

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