Drug Information

Drug General Information
Drug ID
D04QPD
Former ID
DIB010244
Drug Name
FV-100
Synonyms
CF-1001; CF-1094; CF-1368; CF-1369; CF-1449; CF-1452; CF-1698; CF-1712; CF-1743; CF-1821; CF-1835; CF-1837; CF-1838; CF-1851; CF-2004; CF-2160; CF-2161; CF-2200; BCNAs (antiviral), FermaVir Pharmaceuticals; Bicyclic nucleoside analogs (VZV infection), FermaVir; Bicyclic nucleoside analogs (VZV infection), Inhibitex; Antivirals (nucleoside derivatives), Welsh School of Pharmacy/Rega; BCNAs (antiviral), Rega/Welsh School of Pharmacy; Bicyclic nucleoside analogs (antiviral), Rega/Welsh School of Pharmacy
Indication Adult varicella zoster virus infection [ICD10:B02] Phase 3 [525145]
Company
Welsh School of Pharmacy
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(c(=O)nc2c(c1)cc(o2)c1ccc(cc1)CCCCC)[C@@H]1O[C@@H]([C<br />@H](C1)O)COC(=O)[C@@H](N)C(C)C
Target and Pathway
Target(s) Thymidine kinase Target Info Inhibitor [526256]
References
Ref 525145ClinicalTrials.gov (NCT02412917) A Comparative Study of FV-100 vs. Valacyclovir for the Prevention of Post-Herpetic Neuralgia. U.S. National Institutes of Health.
Ref 526256Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Mol Pharmacol. 2002 Feb;61(2):249-54.

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