Drug Information

Drug General Information
Drug ID
D08GIM
Former ID
DIB013107
Drug Name
Elisidepsin
Synonyms
Irvalec; Elisidepsin trifluoroacetate; PM-02734; Erbb3 tyrosine kinase receptor inhibitor (cancer), PharmaMar; Kahalalide therapy (solid tumor), PharmaMar
Indication Psoriasis [ICD9: 696; ICD10:L40] Phase 2 [533234]
Company
PharmaMar SA
Structure
Download
2D MOL

3D MOL
Formula
C77H125F3N14O18
Canonical SMILES
N1(C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(<br />=O)CC[C@H](CC)C)C(C)C)[C@H](O)C)C(C)C)C(C)C)[C@@H](C(=O<br />)N[C@H](C(=O)N[C@@H](C(=O)N[C@H]2C(=O)N[C@@H](C(=O)N[C@<br />@H](C(=O)N[C@H](C(=O)N/C(=C\C)/C(=O)N[C@H](C(=O)O[C@@H]<br />2C)C(C)C)Cc2ccccc2)C(C)C)[C@H](CC)C)[C@H](CC)C)CCCN)CCC<br />1
PubChem Compound ID
56841992
Target and Pathway
Target(s) Receptor protein-tyrosine kinase erbB-3 Target Info Inhibitor [530057]
KEGG Pathway ErbB signaling pathway
Calcium signaling pathway
Endocytosis
Proteoglycans in cancer
MicroRNAs in cancer
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
EGF receptor signaling pathway
Pathway Interaction Database ErbB2/ErbB3 signaling events
ErbB receptor signaling network
a6b1 and a6b4 Integrin signaling
WikiPathways ErbB Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling Pathways in Glioblastoma
miR-targeted genes in muscle cell - TarBase
Heart Development
References
Ref 533234First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors. Invest New Drugs. 2015 Aug;33(4):901-10.
Ref 530057Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models. Eur J Cancer. 2009 Jul;45(10):1855-64.

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