Drug General Information
Drug ID
D0B1FE
Former ID
DAP001372
Drug Name
Ebselen
Synonyms
Ebselene; Ebseleno; Ebselenum; Harmokisane; Ebselen [INN]; Ebselene [French]; Ebseleno [Spanish]; Ebselenum [Latin]; DR 3305; E 3520; PZ 51; PZ51; RP 60931; DR-3305; PZ-51; SPI-1005; SPI-3005; 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; 2-Phenyl-1,2-benzisoselenazolin-3-one; 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 2-phenyl-1,2-benzoselenazol-3-one
Drug Type
Small molecular drug
Indication Reperfusion injury and stroke [ICD9: 410, 434.91; ICD10:I21, I22, I61-I63] Approved [536373]
Therapeutic Class
Fibrinolytic Agents
Structure
Download
2D MOL

3D MOL

Formula
C13H9NOSe
Canonical SMILES
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChI
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChIKey
DYEFUKCXAQOFHX-UHFFFAOYSA-N
CAS Number
CAS 60940-34-3
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Serum albumin Target Info Binder [537897]
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
Reactome Platelet degranulation
Recycling of bile acids and salts
HDL-mediated lipid transport
Scavenging of heme from plasma
WikiPathways Human Complement System
Binding and Uptake of Ligands by Scavenger Receptors
Lipid digestion, mobilization, and transport
Transport of vitamins, nucleosides, and related molecules
Bile acid and bile salt metabolism
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 536373Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112.
Ref 537897Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. Biochem Pharmacol. 1994 Sep 15;48(6):1137-44.

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