Drug Information
Drug General Information | |||||
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Drug ID |
D0NU0U
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Former ID |
DNCL002653
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Drug Name |
AZD4547
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Drug Type |
Small molecular drug
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Company |
AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C26H33N5O3
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InChI |
InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
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InChIKey |
VRQMAABPASPXMW-HDICACEKSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
117699613, 135610501, 136340324, 136350053, 136920281, 136970544, 140819315, 144115667, 152159627, 163643100, 164041821, 172918164, 174006594, 174525910, 185997025, 190361859, 193883042, 198940588, 223366040, 223367238, 223404365, 223436471, 223471434, 223702523, 224188020, 226445213, 240205758, 241383730, 242587692, 248906639, 249818642, 249869575, 252110149, 252160568, 252442834, 252451807, 252470587
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Target and Pathway | |||||
Target(s) | Basic fibroblast growth factor receptor 1 | Target Info | Modulator | [531819] | |
KEGG Pathway | MAPK signaling pathway | ||||
Ras signaling pathway | |||||
Rap1 signaling pathway | |||||
PI3K-Akt signaling pathway | |||||
Adherens junction | |||||
Signaling pathways regulating pluripotency of stem cells | |||||
Regulation of actin cytoskeleton | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
Prostate cancer | |||||
Melanoma | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
FGF signaling pathway | |||||
Pathway Interaction Database | Glypican 1 network | ||||
Syndecan-4-mediated signaling events | |||||
N-cadherin signaling events | |||||
FGF signaling pathway | |||||
References | |||||
Ref 524785 | ClinicalTrials.gov (NCT02154490) Lung-MAP: S1400 Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IIIB-IV Squamous Cell Lung Cancer. U.S. National Institutes of Health. | ||||
Ref 542682 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7707). |
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