Drug Information
Drug General Information | |||||
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Drug ID |
D0Y6UU
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Former ID |
DCL000296
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Drug Name |
Atrasentan
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Synonyms |
Xinlay; Atrasentan [INN]; A 127722; A 147627; ABT 627; A-127722; A-147627; ABT-627; Xinlay (TN); A-127722.5; (+)-A 127722; (+)-A-127722; (11C)ABT-627; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid; 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(((dibutylamino)carbonyl)methyl)pyrrolidine-3-carboxylic acid; 2R-(4-methoxyphenyl)-4S(1,3-benzodioxol-5-yl)-1-(N,N-di(n-butyl)aminocarbonyl-methyl)-pyrrolidine-3R-carboxylic acid
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Drug Type |
Small molecular drug
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Company |
Abbott
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Structure |
Download2D MOL |
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Formula |
C29H38N2O6
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InChI |
InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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InChIKey |
MOTJMGVDPWRKOC-QPVYNBJUSA-N
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CAS Number |
CAS 195733-43-8
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PubChem Compound ID | |||||
PubChem Substance ID |
535748, 10253652, 12014999, 14811316, 14909273, 46234806, 50068170, 50253083, 53788137, 53789849, 57348721, 103168476, 103948098, 113442732, 127346318, 128626310, 134338952, 134339653, 135115498, 135325628, 137006712, 141972835, 163620866, 163686195, 178100477, 179150068, 185974011, 198977266, 224005477, 226421083
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Target and Pathway | |||||
Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [535545] | |
NetPath Pathway | IL4 Signaling Pathway | ||||
PANTHER Pathway | Endothelin signaling pathway | ||||
Pathway Interaction Database | Endothelins | ||||
EGFR-dependent Endothelin signaling events | |||||
References | |||||
Ref 536957 | Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. | ||||
Ref 540426 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3487). |
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