Drug General Information
Drug ID	D0D7UD
Former ID	DIB002523
Drug Name	AS-013
Synonyms	Circulase; Ecraprost; Prostaglandin E1 (liposomal), Mitsubishi Pharma/Asahi Glass
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Phase 3	[534768]
Company	Taisho Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C28H48O6
Canonical SMILES	C1(=C([C@@H](/C=C/[C@@H](O)CCCCC)[C@@H](C1)O)CCCCCCC(=O<br />)OCCCC)OC(=O)CCC
CAS Number	CAS 136892-64-3
PubChem Compound ID	6917049
Target and Pathway
Target(s)	Prostaglandin E2 receptor, EP1 subtype	Target Info	Agonist	[534768]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Pathways in cancer
PANTHER Pathway	PI3 kinase pathway
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 534768	Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):203-7.
Ref 534768	Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):203-7.

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