Drug Information

Drug General Information
Drug ID
D0TP9M
Former ID
DNCL002535
Drug Name
ACY-1215
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1/2 [524684], [542040]
Company
Acetylon Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C24H27N5O3
InChI
InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
InChIKey
QGZYDVAGYRLSKP-UHFFFAOYSA-N
PubChem Compound ID
53340666
PubChem Substance ID
125005606, 138910892, 161005252, 162012001, 163370731, 163620996, 163686328, 164144445, 164193966, 174006356, 175451991, 176253792, 178103589, 186022497, 189253967, 198988199, 219813871, 223391680, 223637710, 223705206, 226880432, 249859092, 250220890, 251962941, 252071791, 252214662, 252445340, 252552933
Target and Pathway
Target(s) Histone deacetylase Target Info Modulator [544487]
Histone deacetylase 6 Target Info Modulator [544487]
KEGG Pathway Alcoholism
Viral carcinogenesis
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary cilium
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell Cycle
References
Ref 524684ClinicalTrials.gov (NCT02091063) ACY-1215 for Relapsed/Refractory Lymphoid Malignancies. U.S. National Institutes of Health.
Ref 542040(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7010).
Ref 544487Promising therapies in multiple myeloma. Blood. 2015 July 16; 126(3): 300-310.

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