Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R3MT
|
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| Former ID |
DIB003896
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| Drug Name |
Acadesine
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| Synonyms |
AICAR; Acadra; ADV-P1; ATH-001; Acadesine (intravenous formulation, leukemia); Acadesine (intravenous formulation, leukemia), Advanced In Vitro Cell Technologies
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| Drug Type |
Small molecular drug
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| Company |
Schering-Plough
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| Structure |
|
Download2D MOL |
|||
| Formula |
C9H14N4O5
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| InChI |
InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
|
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| InChIKey |
RTRQQBHATOEIAF-UUOKFMHZSA-N
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| CAS Number |
CAS 2627-69-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
8163117, 14774569, 14847938, 17396905, 24715152, 26758179, 29217492, 29285249, 48018877, 57329792, 74850498, 85247950, 89113390, 104253388, 104342656, 104548352, 118046859, 121379620, 124757506, 124893186, 124971563, 125164310, 126671490, 129180315, 129951236, 131477474, 134222485, 134982255, 136349962, 137100921, 137260954, 137673016, 144205104, 162011958, 162037727, 162171410, 163391816, 163688649, 163843374, 164175269, 165245652, 170465608, 172097137, 175426912, 176484784, 178101825, 179150239, 184565448, 198939288, 223438380
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| Target and Pathway | |||||
| Target(s) | AMP-activated protein kinase | Target Info | Modulator | [529621] | |
| KEGG Pathway | FoxO signaling pathway | ||||
| Regulation of autophagy | |||||
| mTOR signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Circadian rhythm | |||||
| Insulin signaling pathway | |||||
| Adipocytokine signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Glucagon signaling pathway | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| References | |||||
| Ref 468196 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5133). | ||||
| Ref 529621 | Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother. 2008 Aug;9(12):2137-44. | ||||
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