TTD | Drug: D08KDK

Drug General Information
Drug ID	D08KDK
Former ID	DIB016796
Drug Name	T-2007
Synonyms	DPB sodium; Diphenylbarbituric sodium; Diphenylbarbituric acid (epilepsy), Taro; 5,5-diphenylbarbituric sodium
Indication	Epilepsy [ICD10:G40]		Phase 2	[522725]
Company	Taro Pharmaceutical Industries Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(C(=O)NC(=O)NC1=O)(c1ccccc1)c1ccccc1.[Na+]
Target and Pathway
Target(s)	GABA A receptor	Target Info	Agonist	[543814]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 522725	ClinicalTrials.gov (NCT00939653) T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML). U.S. National Institutes of Health.
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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Drug Information