Drug Information

Drug General Information
Drug ID
D09JEJ
Former ID
DNCL002399
Drug Name
CX-4945
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [523166], [542980]
Company
Cylene Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H12ClN3O2
InChI
InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
InChIKey
MUOKSQABCJCOPU-UHFFFAOYSA-N
PubChem Compound ID
24748573
PubChem Substance ID
49650657, 56164317, 103162249, 104246358, 123051134, 124360792, 125085740, 125164705, 125165310, 126661317, 126731254, 131549349, 135685370, 135685371, 135685390, 135723839, 136340300, 136349493, 136367624, 137230123, 137276036, 137525053, 143499362, 144115861, 152227610, 152234787, 152255064, 152258833, 152344058, 160647684, 160821183, 162011979, 162038030, 162202620, 163091488, 163372958, 164045277, 165241316, 172093670, 172913316, 174006751, 174561036, 180386992, 186020726, 189616233, 198951496, 203090868, 204389294, 223258866, 223375362
Target and Pathway
Target(s) Casein kinase 2 Target Info Modulator [532443]
References
Ref 523166ClinicalTrials.gov (NCT01199718) Study of CX-4945 in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 542980(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8126).
Ref 532443CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway. Leukemia. 2013 Oct;27(10):2094-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.