Drug General Information
Drug ID	D0OZ4F
Former ID	DIB007760
Drug Name	Ordopidine
Synonyms	ACR-321; ACR-325
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Discontinued in Phase 1	[548392]
Company	A Carlsson Research AB
Structure		Download 2D MOL 3D MOL
Formula	C14H20FNO2S
Canonical SMILES	c1c(c(c(cc1)C1CCN(CC1)CC)F)S(=O)(=O)C
CAS Number	CAS 871351-60-9
PubChem Compound ID	11701939
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Modulator	[532776]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 548392	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025217)
Ref 532776	The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression. J Neural Transm. 2014 Nov;121(11):1337-47.

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