Drug Information

Drug General Information
Drug ID
D08WYH
Former ID
DIB015097
Drug Name
LY-2228820
Synonyms
LY-2180895; LY-2211877; LY-2228820 mesylate; LY-2231377; LY-2322600; LY-479754; LY-2228820.2MsOH; P38 MAP kinase inhibitors (inflammation, cancer), Lilly
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1/2 [524019], [542875]
Company
Lilly
Structure
Download
2D MOL

3D MOL
Formula
C24H29FN6
InChI
InChI=1S/C24H29FN6/c1-23(2,3)13-31-20-17(28-22(31)26)12-11-16(27-20)19-18(14-7-9-15(25)10-8-14)29-21(30-19)24(4,5)6/h7-12H,13H2,1-6H3,(H2,26,28)(H,29,30)
InChIKey
XPPBBJCBDOEXDN-UHFFFAOYSA-N
PubChem Compound ID
11539025
PubChem Substance ID
16641134, 16641135, 42657044, 56483402, 79612821, 136367893, 144116160, 162202583, 163370728, 164130396, 174007016, 198984593, 201508889, 224243604, 229956452, 238816232, 242060150, 248489409, 249565642, 252109929, 252110015, 252160548, 252472362
Target and Pathway
Target(s) Stress kinase p38 Target Info Inhibitor [542875]
References
Ref 524019ClinicalTrials.gov (NCT01663857) A Study of LY2228820 for Recurrent Ovarian Cancer. U.S. National Institutes of Health.
Ref 542875(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7959).
Ref 542875(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7959).

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