Drug Information

Drug General Information
Drug ID
D0PQ8T
Former ID
DNC009268
Drug Name
SB-436811
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 1 [523601], [539371]
Structure
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2D MOL

3D MOL
Formula
C23H29Cl2N3O2
InChI
InChI=1S/C23H29Cl2N3O2/c1-27(2)11-3-13-30-20-7-4-17(5-8-20)15-28-12-10-19(16-28)26-23(29)18-6-9-21(24)22(25)14-18/h4-9,14,19H,3,10-13,15-16H2,1-2H3,(H,26,29)/t19-/m0/s1
InChIKey
AMSSIFVGNFEEFU-IBGZPJMESA-N
PubChem Compound ID
9846574
PubChem Substance ID
14808573, 16619988, 24143593, 44944642, 77640748, 103460958, 104098526, 134346473, 135651009, 137074914, 172918241, 232621633
Target and Pathway
Target(s) Urotensin II receptor Target Info Inhibitor [530610]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523601ClinicalTrials.gov (NCT01424280) Single Dose Study of GSK1440115 in Patients With Asthma. U.S. National Institutes of Health.
Ref 539371(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2164).
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.

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