Drug Information

Drug General Information
Drug ID
D01ZBF
Former ID
DIB015098
Drug Name
E-1224
Synonyms
BMS-292655; BMS-315801; BMS-379224; Ravuconazole prodrugs, BMS; Ravuconazole back-up compounds, Eisai; Ravuconazole prodrug (fungal infection), Brain Factory; Ravuconazole prodrugs, Bristol-Myers Squibb
Drug Type
Small molecular drug
Indication Fungal infections [ICD9: 110-118; ICD10:B35-B49] Phase 2 [523720]
Company
Bristol-Myers Squibb Co
Structure
Download
2D MOL

3D MOL
Formula
C15H20BNO3
Canonical SMILES
[C@@]([C@H](c1nc(cs1)c1ccc(C#N)cc1)C)(c1c(cc(cc1)F)F)(C<br />n1ncnc1)OCOP(=O)(O)O.N[C@H](C(=O)O)CCCCN.N[C@H](C(=O)O)<br />CCCCN
CAS Number
CAS 351228-71-2
PubChem Compound ID
57416740
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [532173]
References
Ref 523720ClinicalTrials.gov (NCT01489228) Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease. U.S. National Institutes of Health.
Ref 532173Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease. Int J Parasitol Drugs Drug Resist. 2012 Dec;2:236-242.

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