Drug Information

Drug General Information
Drug ID
D0RH3S
Former ID
DIB014153
Drug Name
DC/I540/KLH vaccine
Synonyms
HTERT:540-548; Telomerase: 540-548 peptide vaccine; DC/I540/KLH vaccine (cancer); Dendritic cell/hTERT peptide I540/keyhole limpet hemocyanin vaccine, Dana-Farber; DC/I540/KLH vaccine (cancer), Dana-Farber
Drug Type
Vaccine
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Phase 1 [528257]
Company
Dana-Farber Cancer Institute Inc
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info [526963]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 528257Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. Blood. 2006 Oct 15;108(8):2662-8. Epub 2006 Jun 15.
Ref 526963Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res. 2004 Feb 1;10(3):828-39.

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