Drug Information

Drug General Information
Drug ID
D07JBE
Former ID
DIB015306
Drug Name
CG-200745
Synonyms
CG-0006; CG-005; HDAC inhibitors (cancer, oral/intravenous), CrystalGenomics; Histone deacetylase inhibitors (cancer, oral/intravenous), CrystalGenomics
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [523222]
Company
CrystalGenomics Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1ccc2c(c1)cccc2OC/C(=C\CCCCC(=O)NO)/C(O)NCCCN(C)C
Target and Pathway
Target(s) Histone deacetylase Target Info Inhibitor [533181]
References
Ref 523222ClinicalTrials.gov (NCT01226407) Examine Maximum Tolerated Dose and Pharmacokinetic and Pharmacodynamic Profile. U.S. National Institutes of Health.
Ref 533181Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One. 2015 Mar 17;10(3):e0119379.

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