Drug Information

Drug General Information
Drug ID
D04KHH
Former ID
DIB000843
Drug Name
CEFCANEL DALOXATE HYDROCHLORIDE
Synonyms
Loride; Onohydrochloride; Enylethyl ester monohydrochloride; KY-109; Cefcanel daloxate hydrochloride < Rec INNM >; (5-Methyl-1,3-dioxolen-2-on-4-ylmethyl) 7-[D-O-(L-alanyl)mandelamido]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylate hydrochloride; (5-Methyl-2-oxo-1,3-dioxo-4-yl)methyl (6R,7R)-7-[(R)-2-[(S)-alanyloxy]-2-phenylacetamido]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydroch; (6R,7R)-7beta-[2(R)-(S-Alanyloxy)-2-phenylacetamido]-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; L-Alanine [6R-[6alpha,7beta(R*)]]-2-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-2-oxo-1-ph; 2,3-Dihydroxy-2-butenyl (6R,7R)-7-[(R)-mandelamido]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,cyclic-2,3-carbonate,ester with L-alanine m
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Discontinued in Phase 3 [545259]
Structure
Download
2D MOL

3D MOL
Formula
C27H28ClN5O9S3
Canonical SMILES
CC1=C(OC(=O)O1)COC(=O)C2=C(CSC3N2C(=O)C3NC(=O)C(C4=CC=C<br />C=C4)OC(=O)C(C)N)CSC5=NN=C(S5)C.Cl
InChI
1S/C27H27N5O9S3.ClH/c1-12(28)24(35)41-20(15-7-5-4-6-8-15)21(33)29-18-22(34)32-19(25(36)38-9-17-13(2)39-27(37)40-17)16(10-42-23(18)32)11-43-26-31-30-14(3)44-26;/h4-8,12,18,20,23H,9-11,28H2,1-3H3,(H,29,33);1H/t12-,18+,20+,23+;/m0./s1
InChIKey
HFVATKYQUGKLGL-PCQLZLFJSA-N
CAS Number
CAS 92602-21-6
PubChem Compound ID
179696
PubChem Substance ID
10259174, 12013482, 14937499, 33502782, 49864866, 50876785, 57395694, 104430277, 135158630, 228358363
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Modulator [533920]
References
Ref 545259Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002619)
Ref 533920Pharmacokinetics of oral cefcanel daloxate hydrochloride in healthy volunteers and patients with various degrees of impaired renal function. J Antimicrob Chemother. 1994 Feb;33(2):281-8.

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