Drug Information

Drug General Information
Drug ID
D0ZE9C
Former ID
DIB001153
Drug Name
PAZINACLONE
Synonyms
A-77000; DN-2327; Pazinaclone < Rec INN; Rac-8-[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 3 [544719]
Structure
Download
2D MOL

3D MOL
Formula
C25H23ClN4O4
Canonical SMILES
Clc1ccc2ccc(nc2n1)N3C(CC(=O)N4CCC5(CC4)OCCO5)C6C=CC=CC6<br />C3=O
InChI
1S/C25H25ClN4O4/c26-20-7-5-16-6-8-21(28-23(16)27-20)30-19(17-3-1-2-4-18(17)24(30)32)15-22(31)29-11-9-25(10-12-29)33-13-14-34-25/h1-8,17-19H,9-15H2
InChIKey
ODCORAJVSLDYFP-UHFFFAOYSA-N
CAS Number
CAS 103255-66-9
PubChem Compound ID
59743
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [536090]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 544719Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000717)
Ref 536090The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs. 2005 May;14(5):601-18.

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