Drug Information

Drug General Information
Drug ID
D07VPG
Former ID
DIB016456
Drug Name
BW-773U82
Synonyms
BW-A773U; 2-(3-Fluoranthenylmethylamino)-2-methyl-1,3-propanediol hydrochloride; 3-[2-Hydroxy-1-(hydroxymethyl)-1-methylethylaminomethyl]fluoranthene hydrochloride; 773U82.HCl
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545287]
Structure
Download
2D MOL

3D MOL
Formula
C21H22ClNO2
Canonical SMILES
CC(CO)(CO)NCC1=C2C=CC=C3C2=C(C=C1)C4=CC=CC=C43.Cl
InChI
1S/C21H21NO2.ClH/c1-21(12-23,13-24)22-11-14-9-10-19-17-6-3-2-5-16(17)18-8-4-7-15(14)20(18)19;/h2-10,22-24H,11-13H2,1H3;1H
InChIKey
XPSPHVAGYMFPFA-UHFFFAOYSA-N
CAS Number
CAS 96404-51-2
PubChem Compound ID
3024572
PubChem Substance ID
10043118, 14778785, 36069719, 50021437, 79838846, 103671409, 111661344, 135214664, 224863640, 235774324
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [534741]
References
Ref 545287Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002707)
Ref 534741Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols. Anticancer Drug Des. 1998 Oct;13(7):825-35.

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