Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ML2V
|
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| Former ID |
DIB004814
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| Drug Name |
RALURIDINE
|
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| Synonyms |
FCU; FddClUrd; BW-935U83; Raluridine < USAN >; 5-Chloro-2',3'-dideoxy-3'-fluorouridine
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
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| Formula |
C9H10ClFN2O4
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| Canonical SMILES |
OC[C@H]1O[C@H](C[C@@H]1F)N2C=C(Cl)C(=O)NC2=O
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| InChI |
1S/C9H10ClFN2O4/c10-4-2-13(9(16)12-8(4)15)7-1-5(11)6(3-14)17-7/h2,5-7,14H,1,3H2,(H,12,15,16)/t5-,6+,7+/m0/s1
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| InChIKey |
WKVDSZYIGHLONN-RRKCRQDMSA-N
|
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| CAS Number |
CAS 119644-22-3
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | HIV reverse transcriptase | Target Info | Inhibitor | [533617], [551871] | |
| References | |||||
| Ref 521438 | ClinicalTrials.gov (NCT00002338) The Safety and Effectiveness of 935U83 in HIV-Infected Patients. U.S. National Institutes of Health. | ||||
| Ref 534371 | Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother. 1996 Dec;40(12):2842-7. | ||||
| Ref 533617 | 5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile. Antimicrob Agents Chemother. 1994 Jul;38(7):1590-603. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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