Drug Information
Drug General Information | |||||
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Drug ID |
D0I5IM
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Former ID |
DIB001496
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Drug Name |
LY-518674
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Synonyms |
LY-674; 2-Methyl-2-[4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid
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Drug Type |
Small molecular drug
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Company |
Eli Lilly
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Structure |
Download2D MOL |
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Formula |
C23H27N3O4
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InChI |
InChI=1S/C23H27N3O4/c1-16-7-9-18(10-8-16)15-26-22(29)24-20(25-26)6-4-5-17-11-13-19(14-12-17)30-23(2,3)21(27)28/h7-14H,4-6,15H2,1-3H3,(H,27,28)(H,24,25,29)
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InChIKey |
PNHFDVSKDSLUFH-UHFFFAOYSA-N
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CAS Number |
CAS 425671-29-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Peroxisome proliferator activated receptor alpha | Target Info | Agonist | [529793] | |
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | ||||
Reactome | RORA activates gene expression | ||||
BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||||
PPARA activates gene expression | |||||
YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
Transcriptional activation of mitochondrial biogenesis | |||||
Activation of gene expression by SREBF (SREBP) | |||||
Transcriptional regulation of white adipocyte differentiation | |||||
Nuclear Receptor transcription pathway | |||||
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
Circadian Clock | |||||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Nuclear Receptors Meta-Pathway | |||||
Estrogen Receptor Pathway | |||||
PPAR Alpha Pathway | |||||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
Transcriptional Regulation of White Adipocyte Differentiation | |||||
YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
Activation of Gene Expression by SREBP (SREBF) | |||||
Adipogenesis | |||||
SREBF and miR33 in cholesterol and lipid homeostasis | |||||
Circadian Clock | |||||
Nuclear Receptors | |||||
References | |||||
Ref 521832 | ClinicalTrials.gov (NCT00327002) A Mechanistic Study of the Effects of LY518674 on High-Density Lipoprotein Cholesterol (HDL-C) Metabolism. U.S. National Institutes of Health. | ||||
Ref 539724 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2658). |
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