Drug General Information
Drug ID
D02VJY
Former ID
DAP001352
Drug Name
Biricodar
Synonyms
Incel; Biricodar [INN]; Vx 710; Incel (TN); 1,7-dipyridin-3-ylheptan-4-yl (2S)-1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Approved [536248]
Therapeutic Class
Anticancer Agents
Company
Vertex Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C34H41N3O7
Canonical SMILES
COC1=CC(=CC(=C1OC)OC)C(=O)C(=O)N2CCCCC2C(=O)OC(CCCC3=CN<br />=CC=C3)CCCC4=CN=CC=C4
InChI
1S/C34H41N3O7/c1-41-29-20-26(21-30(42-2)32(29)43-3)31(38)33(39)37-19-5-4-16-28(37)34(40)44-27(14-6-10-24-12-8-17-35-22-24)15-7-11-25-13-9-18-36-23-25/h8-9,12-13,17-18,20-23,27-28H,4-7,10-11,14-16,19H2,1-3H3/t28-/m0/s1
InChIKey
CGVWPQOFHSAKRR-NDEPHWFRSA-N
CAS Number
CAS 174254-13-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Multidrug resistance protein 1 Target Info Modulator
KEGG Pathway ABC transporters
Bile secretion
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome ABC-family proteins mediated transport
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Abacavir transport and metabolism
Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Drug Induction of Bile Acid Pathway
Codeine and Morphine Metabolism
References
Ref 536248Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets. 2006 Jul;7(7):861-79.

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