Drug Information
Drug General Information | |||||
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Drug ID |
D01DVX
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Former ID |
DPR000038
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Drug Name |
DPC-333
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Drug Type |
Small molecular drug
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Company |
Bristol-Myers Squibb Pharma
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Structure |
Download2D MOL |
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Formula |
C27H32N4O4
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InChI |
InChI=1S/C27H32N4O4/c1-17(2)14-24(25(32)30-34)31-13-12-27(28,26(31)33)20-8-10-21(11-9-20)35-16-19-15-18(3)29-23-7-5-4-6-22(19)23/h4-11,15,17,24,34H,12-14,16,28H2,1-3H3,(H,30,32)/t24-,27-/m1/s1
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InChIKey |
QVNZBDLTUKCPGJ-SHQCIBLASA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | ADAM 17 | Target Info | Inhibitor | [536223] | |
Pathway Interaction Database | ErbB4 signaling events | ||||
TNF receptor signaling pathway | |||||
p75(NTR)-mediated signaling | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Collagen degradation | |||||
Regulated proteolysis of p75NTR | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 t(7 | |||||
M1580_K2555) Translocation Mutant | |||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
TNF signaling | |||||
Growth hormone receptor signaling | |||||
References | |||||
Ref 536223 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. | ||||
Ref 541646 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6509). |
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