Drug Information

Drug General Information
Drug ID
D0E1VV
Former ID
DIB005543
Drug Name
ELOMOTECAN HYDROCHLORIDE
Synonyms
BN-80927; R-1559; Elomotecan hydrochloride < Prop INNM >; (+)-9-Chloro-5(R)-ethyl-5-hydroxy-10-methyl-12-(4-methylpiperidin-1-ylmethyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione hydrochloride
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [523624]
Structure
Download
2D MOL

3D MOL
Formula
C29H33Cl2N3O4
Canonical SMILES
CCC1(CC(=O)OCC2=C1C=C3C4=NC5=CC(=C(C=C5C(=C4CN3C2=O)CN6<br />CCC(CC6)C)C)Cl)O.Cl
InChI
1S/C29H32ClN3O4.ClH/c1-4-29(36)12-26(34)37-15-21-22(29)10-25-27-20(14-33(25)28(21)35)19(13-32-7-5-16(2)6-8-32)18-9-17(3)23(30)11-24(18)31-27;/h9-11,16,36H,4-8,12-15H2,1-3H3;1H/t29-;/m1./s1
InChIKey
OLYFGLXPXPABOP-XXIQNXCHSA-N
CAS Number
CAS 220997-99-9
PubChem Compound ID
216300
PubChem Substance ID
9372842, 14886253, 30420033, 50771485, 57399772, 103067186, 103083296, 113461344, 117447165, 135134629, 162816875, 198940843
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 523624ClinicalTrials.gov (NCT01435096) BN80927 in Patients With Advanced Malignant Solid Tumors. U.S. National Institutes of Health.

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