Drug Information

Drug General Information
Drug ID
D05SFD
Former ID
DIB000375
Drug Name
DMP-961
Synonyms
DPC-961; (-)-6-Chloro-4(S)-(2-cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 2 [546920]
Structure
Download
2D MOL

3D MOL
Formula
C14H10ClF3N2O
Canonical SMILES
C1CC1C#CC2(C3=C(C=CC(=C3)Cl)NC(=O)N2)C(F)(F)F
InChI
1S/C14H10ClF3N2O/c15-9-3-4-11-10(7-9)13(14(16,17)18,20-12(21)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H2,19,20,21)/t13-/m0/s1
InChIKey
JJWJSIAJLBEMEN-ZDUSSCGKSA-N
CAS Number
CAS 214287-88-4
PubChem Compound ID
474120
PubChem Substance ID
630414, 8032645, 10307746, 14899062, 14899063, 24714762, 57405633, 74565670, 103066764, 103082971, 103201786, 103855641, 109762822, 117502467, 128285720, 135245663, 137237702, 141804053, 162815068, 198942094, 227294705
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [544096], [551871]
References
Ref 546920Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011150)
Ref 544096Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer. AAPS PharmSciTech. 2000 December; 1(4): 55-61.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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