Drug Information

Drug General Information
Drug ID
D09ANC
Former ID
DIB013476
Drug Name
MC-02,479
Synonyms
RWJ-54428; (6R,7R)-7-[2-(2-Amino-5-chlorothiazol-4-yl)-2(Z)-(hydroxyimino)acetamido]-3-[3-(2-aminoethylsulfanylmethyl)pyridin-4-ylsulfanyl]-3-cephem-4-carboxylic acid methanesulfonate
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Discontinued in Phase 1 [546636]
Structure
Download
2D MOL

3D MOL
Canonical SMILES
NCCSCc1cnccc1SC2=C(N3[C@H](SC2)[C@H](NC(=O)\\C(=N/O)\\c<br />4nc(N)sc4Cl)C3=O)C(=O)O
InChI
1S/C20H20ClN7O5S4/c21-15-11(26-20(23)37-15)12(27-33)16(29)25-13-17(30)28-14(19(31)32)10(7-35-18(13)28)36-9-1-3-24-5-8(9)6-34-4-2-22/h1,3,5,13,18,33H,2,4,6-7,22H2,(H2,23,26)(H,25,29)(H,31,32)/b27-12-/t13-,18-/m1/s1
InChIKey
LTUWUNMGTLOPNC-RLQAYIIJSA-N
CAS Number
CAS 189448-35-9
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Inhibitor [526523]
References
Ref 546636Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009332)
Ref 526523Antimicrob Agents Chemother. 2003 Feb;47(2):658-64.RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal beta-lactamases.

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