Drug Information

Drug General Information
Drug ID
D0KR1N
Former ID
DIB009064
Drug Name
PPI-2458
Synonyms
Metapro; 6-O-[N-[1(R)-Carbamoyl-2-methylpropyl]carbamoyl]fumagillol
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1 [521623]
Company
Praecis Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C22H36N2O6
Canonical SMILES
CC(C)C(C(=O)N)NC(=O)OC1CCC2(CO2)C(C1OC)C3(C(O3)CC=C(C)C<br />)C
InChI
1S/C22H36N2O6/c1-12(2)7-8-15-21(5,30-15)18-17(27-6)14(9-10-22(18)11-28-22)29-20(26)24-16(13(3)4)19(23)25/h7,13-18H,8-11H2,1-6H3,(H2,23,25)(H,24,26)/t14-,15-,16-,17-,18-,21+,22+/m1/s1
InChIKey
QBDVVYNLLXGUGN-XGTBZJOHSA-N
PubChem Compound ID
6918653
PubChem Substance ID
12015668, 14807207, 17195022, 43530018, 50171724, 114788309, 135262443, 139068366, 139859475, 140105386, 175427046, 198954902, 229293836, 248953699
Target and Pathway
Target(s) Methionine aminopeptidase 2 Target Info Inhibitor [532203]
Reactome Inactivation, recovery and regulation of the phototransduction cascade
References
Ref 521623ClinicalTrials.gov (NCT00100347) Safety/Tolerance Study of PPI-2458 in Subjects With Non-Hodgkin's Lymphoma and Solid Tumors. U.S. National Institutes of Health.
Ref 532203Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26.

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