Drug Information
Drug General Information | |||||
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Drug ID |
D0N3ZY
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Former ID |
DIB005737
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Drug Name |
DPC-681
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Synonyms |
N-(3-Fluorobenzyl)glycyl-N-[3-[N-(3-aminophenylsulfonyl)-N-isobutylamino]-1(S)-benzyl-2(R)-hydroxypropyl]-3-methyl-L-valinamide mesylate
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Drug Type |
Small molecular drug
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Indication | Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] | Discontinued in Phase 1 | [547252] | ||
Structure |
Download2D MOL |
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Formula |
C35H48FN5O5S
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Canonical SMILES |
CC(C)CN(CC(C(CC1=CC=CC=C1)N(CC2=CC(=CC=C2)F)C(C(=O)NC(=<br />O)CN)C(C)(C)C)O)S(=O)(=O)C3=CC=CC(=C3)N
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InChI |
1S/C35H48FN5O5S/c1-24(2)21-40(47(45,46)29-16-10-15-28(38)19-29)23-31(42)30(18-25-11-7-6-8-12-25)41(22-26-13-9-14-27(36)17-26)33(35(3,4)5)34(44)39-32(43)20-37/h6-17,19,24,30-31,33,42H,18,20-23,37-38H2,1-5H3,(H,39,43,44)/t30-,31?,33-/m0/s1
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InChIKey |
BHPRDABYBCABNU-NCNGZOBXSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | HIV protease | Target Info | Inhibitor | [526167], [551871] | |
References | |||||
Ref 526167 | DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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