Drug Information

Drug General Information
Drug ID
D0V5JO
Former ID
DIB009903
Drug Name
T-0128
Synonyms
M salt; MEN-4901; Glycylglycyl-N-[3-[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yloxy]propyl]glycinamide compound with dextran carboxymethyl ether sodiu
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [547247]
Structure
Download
2D MOL

3D MOL
Formula
C31H36N6O8
Canonical SMILES
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)<br />OCCCNC(=O)CNC(=O)CNC(=O)CN
InChI
1S/C31H36N6O8/c1-3-18-19-10-17(44-9-5-8-33-26(39)13-35-27(40)14-34-25(38)12-32)6-7-23(19)36-28-20(18)15-37-24(28)11-22-21(29(37)41)16-45-30(42)31(22,43)4-2/h6-7,10-11,43H,3-5,8-9,12-16,32H2,1-2H3,(H,33,39)(H,34,38)(H,35,40)/t31-/m0/s1
InChIKey
MWOPHYKKEDTKAZ-HKBQPEDESA-N
CAS Number
CAS 187852-63-7
PubChem Compound ID
71300577
PubChem Substance ID
162108674
Target and Pathway
Target(s) Human DNA Target Info Inhibitor [525789]
References
Ref 547247Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014468)
Ref 525789Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95.

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