Drug Information

Drug General Information
Drug ID
D08AFD
Former ID
DIB013914
Drug Name
NP-252
Synonyms
3-(Cyclopropylcarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid octyl ester
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [544612]
Structure
Download
2D MOL

3D MOL
Formula
C26H35N3O5
Canonical SMILES
CCCCCCCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2[N+](=O)[O-])C(=O<br />)NC3CC3)C)C
InChI
1S/C26H35N3O5/c1-4-5-6-7-8-11-16-34-26(31)23-18(3)27-17(2)22(25(30)28-19-14-15-19)24(23)20-12-9-10-13-21(20)29(32)33/h9-10,12-13,19,24,27H,4-8,11,14-16H2,1-3H3,(H,28,30)
InChIKey
IAWVGADTHVEXRD-UHFFFAOYSA-N
CAS Number
CAS 132031-81-3
PubChem Compound ID
131462
PubChem Substance ID
10242882, 15405558, 29309833, 50031797, 57343798, 80230960, 104375180, 126437150, 135085982, 235180784, 241031497
Target and Pathway
Target(s) Calcium channel Target Info Blocker [529006], [551871]
References
Ref 544612Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000291)
Ref 529006Pharmacological characteristics of NP-252, a new dihydropyridine slow Ca2+ channel blocker, in isolated rabbit vascular smooth muscle and guinea pig myocardium: vascular selectivity. Eur J Pharmacol.1991 Oct 22;203(3):337-44.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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