Drug Information

Drug General Information
Drug ID
D0ZA2L
Former ID
DIB016567
Drug Name
ER-35786
Synonyms
E-1010; (1R,5S,6S)-6-[1(R)-Hydroxymethyl]-2-[2(S)-[1(R)-hydroxy-1-[pyrrolidin-3(R)-yl]methyl]pyrrolidin-4(S)-ylsulfanyl]-1-methyl-1-carba-2-penem-3-carboxylic acid monohydrochloride
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Discontinued in Phase 1 [546021]
Structure
Download
2D MOL

3D MOL
Formula
C19H30ClN3O5S
Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(C4CCNC4)O)C(=O)O)C(C)O.C<br />l
InChI
1S/C19H29N3O5S.ClH/c1-8-14-13(9(2)23)18(25)22(14)15(19(26)27)17(8)28-11-5-12(21-7-11)16(24)10-3-4-20-6-10;/h8-14,16,20-21,23-24H,3-7H2,1-2H3,(H,26,27);1H/t8-,9-,10-,11+,12+,13-,14-,16-;/m1./s1
InChIKey
WRVJTXDJDKITNK-XNGFCKKMSA-N
PubChem Compound ID
6918311
PubChem Substance ID
12014997, 14930878, 14930879, 24667699, 43529691, 75877660, 114787764, 163641917, 198955898, 229108425
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Inhibitor [534319]
References
Ref 546021Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005932)
Ref 534319In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem. Antimicrob Agents Chemother. 1997 Feb;41(2):298-307.

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