Drug General Information
Drug ID	D0R8FM
Former ID	DIB011790
Drug Name	Ebrotidine
Synonyms	Ebrocit; FI-3542
Drug Type	Small molecular drug
Indication	Duodenal ulcers [ICD10:K25-K27]		Withdrawn from market	[544797]
Company	Ferrer Internacional SA
Structure		Download 2D MOL 3D MOL
Formula	C14H17BrN6O2S3
Canonical SMILES	S(=O)(=O)(N/C=N/CCSCc1nc(NC(=N)N)sc1)c1ccc(cc1)Br
CAS Number	CAS 100981-43-9
PubChem Compound ID	65869
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Modulator	[534410]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544797	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001139)
Ref 534410	Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.

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