Drug Information

Drug General Information
Drug ID
D0A8XN
Former ID
DAP000038
Drug Name
Labetalol
Synonyms
Albetol; Ibidomide; Labetalolum; Labetolol; NORMOZIDE; AH 5158; AH-5158; Labetalol (INN); Labetalol [INN:BAN]; Labetalolum [INN-Latin]; Normodyne (TN); Sch-19927; Trandate (TN); 2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzamide; 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide; 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol; 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [538284], [542221]
Therapeutic Class
Antihypertensive Agents
Company
Allen & Handbury
Structure
Download
2D MOL

3D MOL
Formula
C19H24N2O3
InChI
InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
InChIKey
SGUAFYQXFOLMHL-UHFFFAOYSA-N
CAS Number
CAS 36894-69-6
PubChem Compound ID
3869
PubChem Substance ID
9275, 5142009, 7979714, 8152441, 11335649, 11360888, 11364501, 11367063, 11369625, 11372741, 11373866, 11377787, 11461860, 11466305, 11467425, 11484641, 11486109, 11488679, 11491396, 11491999, 11495421, 14777379, 29222985, 46505511, 47216734, 47736423, 47885363, 48184950, 48259181, 48259182, 48259183, 48259184, 48416150, 49698939, 49832659, 49876891, 50105268, 53790399, 56413046, 56464163, 57322029, 77168696, 85209992, 85788805, 90341718, 92716935, 96024796, 103165317, 104304757, 118314781
ChEBI ID
ChEBI:6343
SuperDrug ATC ID
C07AG01
SuperDrug CAS ID
cas=036894696
Target and Pathway
Target(s) Alpha-1 adrenergic receptor Target Info Antagonist [537409]
References
Ref 538284FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074787.
Ref 542221(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7207).
Ref 537409Beta-blockers in the treatment of hypertension: are there clinically relevant differences? Postgrad Med. 2009 May;121(3):90-8.

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