Drug Information

Drug General Information
Drug ID
D0WY9H
Former ID
DNC001532
Drug Name
ZD-0892
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [546659]
Structure
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2D MOL

3D MOL
Formula
C17H11BrClFN2O4
Canonical SMILES
C1=CC2=C(C=C1Cl)N(C(=O)N(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O<br />)O
InChI
1S/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)
InChIKey
SXONDGSPUVNZLO-UHFFFAOYSA-N
CAS Number
CAS 112733-06-9
PubChem Compound ID
5724
PubChem Substance ID
822640, 5366122, 7891218, 8153507, 12014058, 14759400, 17397895, 29224761, 46507491, 46516730, 50040925, 50184937, 57322915, 103064709, 103085748, 103170569, 104310073, 117389120, 124954386, 126591590, 129303239, 134338939, 134340696, 135024687, 137183403, 142347545, 144210777, 160965347, 162311567, 163306697, 170466650, 178103990, 179149602, 184526342, 198947648, 224890862, 226432807
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 546659Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009537)
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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