Drug Information

Drug General Information
Drug ID
D0V3UN
Former ID
DNC000476
Drug Name
CP-80794
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 2 [544930]
Structure
Download
2D MOL

3D MOL
Formula
C32H50N4O8S
Canonical SMILES
CC(C)OC(=O)C(C(C(CC1CCCCC1)NC(=O)C(CSC)NC(=O)C(CC2=CC=C<br />C=C2)NC(=O)N3CCOCC3)O)O
InChI
1S/C32H50N4O8S/c1-21(2)44-31(41)28(38)27(37)24(18-22-10-6-4-7-11-22)33-30(40)26(20-45-3)34-29(39)25(19-23-12-8-5-9-13-23)35-32(42)36-14-16-43-17-15-36/h5,8-9,12-13,21-22,24-28,37-38H,4,6-7,10-11,14-20H2,1-3H3,(H,33,40)(H,34,39)(H,35,42)/t24-,25-,26-,27+,28+/m0/s1
InChIKey
HRFXLRHEKURRIP-APNLASKRSA-N
CAS Number
CAS 119625-78-4
PubChem Compound ID
44301651
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [535823]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544930Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001570)
Ref 535823Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor, CP-80,794, and the angiotensin converting enzyme inhibitor, captopril. J Cardiovasc Pharmacol. 1992 Jul;20(1):75-82.

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