Drug General Information
Drug ID	D02HKL
Former ID	DIB004125
Drug Name	Suriclone
Synonyms	Suril; RP-31264
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Preregistration	[544682]
Company	Rhone-Poulenc SA
Structure		Download 2D MOL 3D MOL
Formula	C20H20ClN5O3S2
Canonical SMILES	N1(C(C2=C(C1=O)SCCS2)OC(=O)N1CCN(CC1)C)c1nc2nc(ccc2cc1)<br />Cl
CAS Number	CAS 53813-83-5
PubChem Compound ID	40903
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[553196]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 544682	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000574)
Ref 553196	The effect of cyclopyrrolones on GABAA receptor function is different from that of benzodiazepines. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):294-300.

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