Drug General Information
Drug ID
D0ZX7I
Former ID
DIB014632
Drug Name
SR-57227
Synonyms
SR-57227A
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Discontinued in Phase 2 [467653], [544942]
Company
Sanofi
Structure
Download
2D MOL

3D MOL

Formula
C10H14ClN3
InChI
InChI=1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2
InChIKey
WPVVMKYQOMJPIN-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) 5-Hydroxytryptamine 3 receptor Target Info Modulator [534182]
References
Ref 467653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4316).
Ref 544942Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001602)
Ref 534182Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83-90.

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